5.30538

cPLA2α Inhibitor II, Pyrrophenone

• 동의어(들): cPLA2α Inhibitor II, Pyrrophenone, Phospholipase A2α Inhibitor
• 실험식(Hill 표기법): C₄₉H₃₇F₂N₃O₅S₂
• CAS Number: 341973-06-6
• Molecular Weight: 849.96
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: powder
• 효능: 4.2 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 100 mg/mL
• 저장 온도: −20°C

설명

일반 설명

Pyrrophenone is a cell-permeable, non-toxic, pyrolidine derivative that acts as a highly potent, and reversible inhibitor of cytosolic phospholipase A2a (cPLA2a; IC50 = 4.2 nM). Does not inhibit the activities of PLA IB and IIA groups even at higher concentrations (~250 µM). Unlike AACOCF3 (Cat. No. 100109), its action is shown to be rapid and does not require a pre-incubation period. Diminishes the release of arachidonic acid (IC50 = 24 nM), prostaglandin E2 (PGE2; IC50 = 25 nM) and leukotriene C4 (IC50 = 14 nM) in A23187 stimulated THP-1 cells. Its effects on production of PGE2 and thromboxane B2 are comparable to those of indomethacin. Also shown to inhibit the lysophospholipase and esterase activity of cPLA2&alpha.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PLA2a

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Please note that the molecular weight for this compound is batch-specific due to variable water content.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable