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Merck
모든 사진(1)

주요 문서

566661

Sigma-Aldrich

SAG

≥95% (HPLC), liquid, smoothened agonist, Calbiochem®

동의어(들):

InSolution Smoothened Agonist, SAG, SAG 1.3 in Solution, SAG1.3 in Solution

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C28H28ClN3OS · 2HCl · xH2O
Molecular Weight:
562.98 (anhydrous basis)
UNSPSC 코드:
12352200
NACRES:
NA.77

product name

Smoothened Agonist, SAG, InSolution, ≥95%, 10 mM aqueous solution

Quality Level

100

분석

≥95% (HPLC)

형태

liquid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

배송 상태

wet ice

저장 온도

−20°C

일반 설명

A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.

재구성

Following initial thaw, aliquot and freeze (-20°C).

기타 정보

Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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