616521

TRPV4 Antagonist II, HC-067047

The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4.

• 동의어(들): TRPV4 Antagonist II, HC-067047, 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047, HC067047, 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II
• 실험식(Hill 표기법): C₂₆H₂₈F₃N₃O₂
• CAS Number: 883031-03-6
• Molecular Weight: 471.51
• MDL number: MFCD01571257
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 50 mg/mL, clear, colorless
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: FC(F)(F)c1cc(ccc1)NC(=O)c2c([n](c(c2)c4ccccc4)CCCN3CCOCC3)C
• InChI key: NCZYSQOTAYFTNM-UHFFFAOYSA-N

설명

일반 설명

A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC₅₀ = 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC₅₀ = 368 and 780 nM, respectively) and little or no activity toward hK_v1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rK_v1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis in vivo.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Everaerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA107, 19084.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable