ABN240

Anti-Beta (β)-Amyloid antibody

rabbit polyclonal

• 동의어(들): Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, 1.N-APP2.Soluble APP-alpha, S-APP-alpha3.Soluble APP-beta, S-APP-beta4.C995.Beta-amyloid protein 42, Be
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 제품명: Anti-Amyloid, β 1-40, aβ Antibody, from rabbit, purified by affinity chromatography
• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 종 반응성(상동성에 의해 예측): bovine (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology)
• 기술: ELISA: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI 수납 번호: NP_001129601
• UniProt 수납 번호: P05067
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... APP(351)

설명

일반 설명

Amyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation.

특이성

This antibody recognizes the P3(40) peptide of Amyloid, β 1-40.

면역원

Epitope: P3(40) peptide

KLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40.

애플리케이션

Anti-Amyloid, β 1-40, aβ Antibody is an antibody against Amyloid, β 1-40, aβ for use in Western Blotting, IHC(P), ELISA.

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Amyloid, B 1-40 in human Alzheimer′s diseased brain tissue.

ELISA: A representative lot detected Amyloid, B 1-40 in ELISA (Direct).

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

품질

Evaluated by Western Blot in human Alzheimer brain tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Amyloid, B 1-40 on 10 µg of human Alzheimer brain tissue lysate.

표적 설명

~4 kDa observed. An uncharacterized band appears at ~19 kDa in some lysates.

결합

Replaces: AB5737

물리적 형태

Affinity purified

Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Human Alzhiemer brain tissue lysate

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable