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Merck
모든 사진(1)

Key Documents

MABT37

Sigma-Aldrich

Anti-Dentin sialoprotein Antibody, clone 2C12.3

clone 2C12.3, from mouse

동의어(들):

Dentin sialophosphoprotein, Dentin phosphoprotein, Dentin phosphophoryn, DPP2.Dentin sialoprotein, DSP

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

2C12.3, monoclonal

종 반응성

mouse, rat

기술

immunohistochemistry: suitable

동형

IgG2bκ

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

mouse ... Dspp(666279)

일반 설명

Dentin sialophosphoprotein (DSPP) is a protein of the extracellular matrix. It belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family. DSPP is found in teeth and bone and is primarily involved in biomineralization processes in these structures. This function may be facilitated by the interaction of DSPP with multiple protein targets including DMP1, BMP2, Runx2, and NF-Y. DSPP plays a central role in dentinogenesis.

면역원

Pure DSP isolated rat dentin

애플리케이션

Anti-Dentin sialoprotein, clone 2C12.3 detects levels of Dentin sialoprotein proteins & has been published & validated for use in IHC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in rat mandibular tissue. (Baba, O., et al. (2004). Eur J Oral Sci. 112:163–170.)
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

품질

Evaluated by Immunohistochemistry in mouse and rat teeth tissues.

Immunohistochemistry Analysis: 1:250-1,000 dilution of this antibody detected Dentin sialophosphoprotein in mouse and rat teeth tissues.

표적 설명

68 kDa calculated. Uniprot describes 2 isoforms at 64 and 70 kDa

물리적 형태

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Mouse and rat teeth tissues

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Xin Gao et al.
Molecular medicine reports, 20(4), 3035-3042 (2019-08-23)
Dental epithelial‑mesenchymal signaling is crucial for tooth development, but the detailed mechanism is not fully understood. Using microarray analysis, it was revealed that the expression of osteoprotegerin, an important factor regulating bone remodeling, significantly increased after removal of the dental
Henry F Duncan et al.
Frontiers in cell and developmental biology, 10, 883266-883266 (2022-05-10)
Matrix-metalloproteinase-13 (MMP13) is important for bone formation and remodeling; however, its role in tooth development remains unknown. To investigate this, MMP13-knockout (Mmp13 -/- ) mice were used to analyze phenotypic changes in the dentin-pulp complex, mineralization-associated marker-expression, and mechanistic interactions.

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