14340

(+)-Bicuculline

≥97.0% (TLC)

• 동의어(들): Bucuculline
• 실험식(Hill 표기법): C₂₀H₁₇NO₆
• CAS Number: 485-49-4
• Molecular Weight: 367.35
• Beilstein: 98786
• EC Number: 207-619-7
• MDL number: MFCD00005006
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329750455
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97.0% (TLC)
• 양식: powder
• 광학 활성: [α]20/D +126±6°, c = 1% in chloroform
• mp: 193-197 °C
• SMILES string: [H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45
• InChI: 1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
• InChI key: IYGYMKDQCDOMRE-ZWKOTPCHSA-N
• 유전자 정보: rat ... Gabra2(29706)

설명

일반 설명

Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

애플리케이션

Bicuculline has been used:

• as a compound to compare pharmacodynamics and network activity profiles of conolidine/cannabidiol
• to study the effects of chronic caffeine administration on the function of GABA_A receptor
• to isolate N-methyl-D-aspartate receptor (NMDAR)-specific evoked and miniature excitatory postsynaptic currents (eEPSCs and mEPSCs) in neurons of rats

생화학적/생리학적 작용

(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.

(+)-Bicuculline is a GABA_A receptor antagonist.

특징 및 장점

This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330,H400
• 예방조치 성명서: P260 - P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges