31679

Chlorpromazine hydrochloride

VETRANAL^®, analytical standard

• 동의어(들): 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil
• 실험식(Hill 표기법): C₁₇H₁₉ClN₂S · HCl
• CAS Number: 69-09-0
• Molecular Weight: 355.33
• Beilstein: 3779989
• EC Number: 200-701-3
• MDL number: MFCD00012654
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329753883
• NACRES: NA.24

속성

• Grade: analytical standard
• Quality Level: 100
• 제품 라인: VETRANAL^®
• 유통기한: limited shelf life, expiry date on the label
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 응용 분야: forensics and toxicology; pharmaceutical (small molecule)
• 형식: neat
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13
• InChI: 1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• InChI key: FBSMERQALIEGJT-UHFFFAOYSA-N
• 유전자 정보: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356)

설명

일반 설명

Chlorpromazine hydrochloride (CPZ) is an antipsychotic drug which belongs to phenothiazine neuroleptic group. It is used in treating mental or personality disorders.

애플리케이션

CPZ may have been used as standard for the determination of antipsychotic drug at a glassy carbon electrode using chemometric methods, such as classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS).

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

생화학적/생리학적 작용

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist, H₁ histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

법적 정보

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H330
• 예방조치 성명서: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges