S0252

Sulfobromophthalein disodium salt hydrate

used to study hepatocyte transport functions

• 동의어(들): BSP, Bromsulfalein sodium disodium salt hydrate
• 실험식(Hill 표기법): C₂₀H₈Br₄Na₂O₁₀S₂ · xH₂O
• CAS Number: 123359-42-2
• Molecular Weight: 838.00 (anhydrous basis)
• EC Number: 200-761-0
• MDL number: MFCD00150017
• UNSPSC 코드: 12171500
• PubChem Substance ID: 24899433
• NACRES: NA.47

속성

• Quality Level: 200
• 형태: powder
• 구성: Water (by Karl Fischer): ≤ 8%; ; Sodium (Na) anhydrous: 4.6-5.8%
• 기술: titration: suitable
• 색상: white to light gray
• solubility: water: 50 mg/mL, clear to hazy
• λmax: 575-581 nm
• 응용 분야: diagnostic assay manufacturing; hematology; histology
• 저장 온도: room temp
• SMILES string: [Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
• InChI: 1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2
• InChI key: CDTNUNQQEUGDSD-UHFFFAOYSA-L

설명

애플리케이션

Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.

생화학적/생리학적 작용

Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334
• 예방조치 성명서: P261 - P280 - P342 + P311
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves