S0883

Sulfasalazine

97.0-101.5%

• 동의어(들): 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine
• 실험식(Hill 표기법): C₁₈H₁₄N₄O₅S
• CAS Number: 599-79-1
• Molecular Weight: 398.39
• Beilstein: 356241
• EC Number: 209-974-3
• MDL number: MFCD00057363
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329824182
• NACRES: NA.24

속성

• Quality Level: 200
• 분석: 97.0-101.5%
• 양식: powder
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• mp: 260-265 °C (dec.) (lit.)
• 응용 분야: forensics and toxicology; pharmaceutical (small molecule)
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• SMILES string: OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
• InChI: 1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
• InChI key: NCEXYHBECQHGNR-QZQOTICOSA-N
• 유전자 정보: human ... ALOX5(240) , PTGS1(5742) , PTGS2(5743)

설명

일반 설명

Chemical structure: sulfonamide

Sulfasalazine (SSZ) belongs to the sulfonamide class of drugs, which can be metabolized into 5-aminosalicylic acid and sulfapyridine. SSZ is obtained as a reaction product of an antibacterial agent (sulfapyridine) and an anti-inflammatory agent (salicylic acid).

애플리케이션

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Sulfasalazine has been used as an analytical standard in clinical studies:

• For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).
• For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.

It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.

안전성 정보

• 픽토그램: GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334,H351,H361f,H411
• 예방조치 성명서: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves