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Merck
모든 사진(1)

문서

SMB00963

Sigma-Aldrich

Desethylchloroquine

≥95% (HPLC)

동의어(들):

7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, 4-[[1-Methyl-4-((ethylamino)butyl]amino)]-7-chloroquinoline, 7-Chloro-4-(4-N-ethylamino-1-methylbutylamino)quinoline, N-Desethyl chloroquine, N-Desethylchloroquine, N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine, Monodeethylchloroquine, Monodesethylchloroqu​ine

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C16H22ClN3
CAS Number:
1476-52-4
Molecular Weight:
291.82
MDL number:
MFCD00871808
UNSPSC 코드:
41116107
NACRES:
NA.77

생물학적 소스

synthetic

Quality Level

200

Grade

research grade

분석

≥95% (HPLC)

형태

powder or crystals

기술

HPLC: suitable

색상

white to off-white

배송 상태

wet ice

저장 온도

2-8°C

SMILES string

ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2

InChI

1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

InChI key

MCYUUUTUAAGOOT-UHFFFAOYSA-N

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일반 설명

Desethylchloroquine is a metabolite of hydroxychloroquine and chloroquine. Hydroxychloroquine and chloroquine have antimalarial properties and are used as a therapeutic for rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. They have also been in the spotlight due to their activity on patients with COVID-19, the disease caused by the SARS-CoV-2 virus. Hydroxychloroquine and chloroquine interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production. Their mode of action is still emerging and their metabolism is of great interest.

애플리케이션

Application: Metabolomics research

기타 정보

For additional information on our range of Biochemicals, please complete this form.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000257597
SLCJ0926

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문서 라이브러리 방문

Gaëlle Noé et al.
Therapeutic drug monitoring, 41(4), 476-482 (2019-02-27)
Hydroxychloroquine (HCQ) is approved for the treatment of systemic lupus erythematosus (SLE). Therapeutic drug monitoring of HCQ is necessary to detect nonadherence and to improve treatment efficacy in patients with SLE. Liquid chromatographic-tandem mass spectroscopy and high performance liquid chromatography
Karnrawee Kaewkhao et al.
Bioanalysis, 11(5), 333-347 (2019-03-16)
Chloroquine is an antimalarial drug used in the treatment of Plasmodium vivax malaria. Three methods to quantify chloroquine and its metabolite in blood matrices were developed and validated. Methodology & results: Different high-throughput extraction techniques were used to recover the
Yingshan Han et al.
Journal of medical virology, 91(7), 1182-1190 (2019-02-26)
Studies aimed at repurposing existing drugs revealed that some antimalarial compounds possess anti-Zika virus (anti-ZIKV) activity. Here, we further tested 14 additional antimalarial drugs and their metabolites or analogs for anti-ZIKV activity using a phenotypic screening approach. We identified four

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