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Merck
모든 사진(1)

문서

SMB01383

Sigma-Aldrich

PhIP

≥95% (HPLC)

동의어(들):

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

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About This Item

실험식(Hill 표기법):
C13H12N4
CAS Number:
Molecular Weight:
224.26
MDL number:
UNSPSC 코드:
12352100
NACRES:
NA.28

생물학적 소스

synthetic

Quality Level

분석

≥95% (HPLC)

형태

solid

배송 상태

2-8°C

저장 온도

2-8°C

SMILES string

NC1=NC2=NC=C(C3=CC=CC=C3)C=C2N1C

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일반 설명

PhIP (2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine) is a dietary genotoxic carcinogen formed in heat processed meat and fish via the Maillard reaction. PhIP is a primary metabolite activated by CYP1A2 and N-acetyltransferase 1 or sulfotransferase to DNA reactive metabolite.

생화학적/생리학적 작용

Carcinogen developed in grilled meats. Induces breast and colon cancer in rats.

픽토그램

Skull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens, such as those in the diet, through a multistep disease process progressing from non-cancerous to premalignant and malignant stages. The chemical carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

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