44583

Doxorubicin hydrochloride

suitable for fluorescence, 98.0-102.0% (HPLC)

• 동의어(들): DOX, Hydroxydaunorubicin hydrochloride
• 실험식(Hill 표기법): C₂₇H₂₉NO₁₁ · HCl
• CAS Number: 25316-40-9
• Molecular Weight: 579.98
• Beilstein: 4229251
• EC Number: 246-818-3
• MDL number: MFCD00077757
• UNSPSC 코드: 51281818
• PubChem Substance ID: 57650234
• NACRES: NA.76

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: 98.0-102.0% (HPLC)
• 양식: solid
• 색상: orange to dark red
• mp: 216 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL, clear, orange to red; DMSO: soluble; THF: soluble; ethanol: soluble; methanol: soluble
• 형광: λ_em 580-590 nm
• 적합성: suitable for fluorescence
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-RUELKSSGSA-N
• 유전자 정보: human ... TOP2A(7153)

설명

일반 설명

Chemical structure: tetracycline

애플리케이션

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

생화학적/생리학적 작용

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H340,H350,H360FD
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges