232120

cis-Diammineplatinum(II) dichloride

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem

• 동의어(들): Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum
• Linear Formula: Pt(NH₃)₂Cl₂
• CAS Number: 15663-27-1
• MDL number: MFCD00011623
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: Cisplatin, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.
• Quality Level: 100
• 설명: Merck USA index - 14, 2317
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: yellow
• solubility: PBS with 140 mM NaCl: 1 mg/mL; water with 154 mM NaCl: 1 mg/mL; DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/2Cl.2H3N.Pt/h;;2*1H3;
• InChI key: JFUARQHXOQHNLK-UHFFFAOYSA-N

설명

일반 설명

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Induces apoptosis in cancer cells

Product does not compete with ATP.

Reversible: no

경고

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

재구성

Unstable in solution; reconstitute just prior to use.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300,H315,H317,H319,H334,H335,H350
• 예방조치 성명서: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable