추천 제품
![Fmoc-Ser[GalNAc(Ac)3-α-D]-OH 95%](/deepweb/assets/sigmaaldrich/product/structures/252/386/8c4549fe-ca62-45cc-b3a5-21b42bdb2b6a/640/8c4549fe-ca62-45cc-b3a5-21b42bdb2b6a.png)
![Fmoc-Thr[GalNAc(Ac)3-α-D]-OH 97%](/deepweb/assets/sigmaaldrich/product/structures/250/325/42734f24-7836-4aaa-ba6a-6284bf7e8181/640/42734f24-7836-4aaa-ba6a-6284bf7e8181.png)
제품명
Tn Antigen, ≥99.0% (TLC)
Quality Level
분석
≥99.0% (TLC)
양식
powder or crystals
저장 온도
−20°C
SMILES string
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
InChI
1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChI key
REDMNGDGDYFZRE-WKWISIMFSA-N
일반 설명
Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
생화학적/생리학적 작용
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation
Liu Z, et al.
Journal of Cellular and Molecular Medicine (2019)
Xichen Dong et al.
BioMed research international, 2018, 9532389-9532389 (2018-07-24)
Immature truncated O-glycans such as Tn antigen are frequently detected in human colorectal cancer (CRC); however, the precise pathological consequences of Tn antigen expression on CRC are unknown. T-synthase is the key enzyme required for biosynthesis of mature O-glycans. Here
Neha M Sahasrabudhe et al.
Biological chemistry, 399(7), 649-659 (2018-06-13)
Colorectal cancer is the third most common cancer type worldwide. It is characterized by a high expression of aberrantly glycosylated ligands, such as the Tn antigen (GalNAcα1-Ser/Thr), which is a major ligand for the C-type lectin macrophage galactose-type lectin (MGL).
Ting-Chun Kuo et al.
Oncogene, 40(7), 1242-1254 (2021-01-10)
Pancreatic adenocarcinoma (PDAC) is a leading cause of cancer-related death. Altered glycosylation contributes to tumor progression and chemoresistance in many cancers. C1GALT1 is the key enzyme controlling the elongation of GalNAc-type O-glycosylation. Here we showed that C1GALT1 was overexpressed in
Catharina Steentoft et al.
Glycobiology, 28(9), 656-669 (2018-01-26)
Cancer immunotherapy is rapidly advancing in the treatment of a variety of hematopoietic cancers, including pediatric acute lymphoblastic leukemia and diffuse large B cell lymphoma, with chimeric antigen receptor (CAR)-T cells. CARs are genetically encoded artificial T cell receptors that
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