모든 사진(1)
About This Item
실험식(Hill 표기법):
C194H295N53O58S
CAS Number:
Molecular Weight:
4329.80
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32
추천 제품
![[Gln22]-Amyloid β 1-40 human ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/images/707/874/59f84b84-17c2-494f-b2ae-4ca860b83976/640/59f84b84-17c2-494f-b2ae-4ca860b83976.jpg)
Amino Acid Sequence
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
일반 설명
Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.
애플리케이션
Amyloid β Protein Fragment 1-40 has been used:
- in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
- as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma
- as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts
생화학적/생리학적 작용
Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels.
Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.
재구성
For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.
기타 정보
Lyophilized from 0.1% TFA in H2O
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
Mehta PD, et al.
Neuroscience Letters, 304(1-2), 102-106 (2001)
Temperature-induced conformational changes in amyloid beta (1-40) peptide investigated by simultaneous FT-IR microspectroscopy with thermal system
Chu HL and Lin SY
Biophysical Chemistry, 89(2-3), 173-180 (2001)
K Ueda et al.
Brain research, 639(2), 240-244 (1994-03-14)
The neurotoxic effects of soluble and aggregated synthetic amyloid beta protein (A beta P) have been investigated in rat primary cultures. Freshly solubilized beta(1-40) was neurotoxic not to immature, but to mature hippocampal neurons. On the other hand, aggregated beta(1-40)
Charlotte E Teunissen et al.
Journal of Alzheimer's disease : JAD, 62(4), 1857-1863 (2018-04-05)
The 42 amino acid form of amyloid-β (Aβ42) plays a key role in the pathogenesis of Alzheimer's disease (AD) and is a core biomarker for the diagnosis of AD. Numerous studies have shown that cerebrospinal fluid (CSF) Aβ42 concentrations are
Sandwich-Type Enzyme Immunoassay for Amyloid A4 Protein in Cerebrospinal Fluid From Patients with Head Trauma
PIRIM I
Turkish Journal of Medical Sciences, 31(1), 47-50 (2001)
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