A1653

Albumin from human serum

lyophilized powder, ≥96% (agarose gel electrophoresis)

• 동의어(들): HSA
• CAS Number: 70024-90-7
• EC Number: 274-272-6
• MDL number: MFCD00081418
• UNSPSC 코드: 12352202
• eCl@ss: 42010201
• NACRES: NA.25

속성

• 생물학적 소스: human
• Quality Level: 300
• 분석: ≥96% (agarose gel electrophoresis)
• 형태: lyophilized powder
• 분자량: monomer calculated mol wt 66478 Da
• 기술: ELISA: suitable; tissue culture: suitable; western blot: suitable
• 불순물: HIV I and HIVII, HCV and HBsAg, tested negative
• solubility: H₂O: soluble 50 mg/mL
• UniProt 수납 번호: P02768
• 저장 온도: 2-8°C
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• 유전자 정보: human ... ALB(213)

설명

일반 설명

Albumin (ALB) constitutes 25% of the proteins produced by the liver. It is a protein of a single polypeptide chain with a thiol group. The ALB gene is mapped to human 4q13.3.

애플리케이션

Albumin from human serum has been used:

• in cyclophilin isomerase assay
• as a component in blocking solution for immunogold quantification of amino acids and proteins in complex subcellular compartments
• in G-pseudotyped HIV (PHIV) assay mixture to study its effect on GSK364735 antiviral potency

Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia.
It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.

생화학적/생리학적 작용

Albumin serves as a protein repository and functions as a binding and transport protein. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This prevents the loss of substance through excretion. Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia.

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.

품질

Remainder mostly globulins

기타 정보

View more information on human serum albumin.

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves