A1755

Aminophylline

≥98%, powder

• 동의어(들): (Theophylline)₂ · Ethylenediamine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1), Theophylline hemi(ethylenediamine) complex
• 실험식(Hill 표기법): C₇H₈N₄O₂ · 0.5C₂H₈N₂
• CAS Number: 317-34-0
• Molecular Weight: 210.21
• EC Number: 206-264-5
• MDL number: MFCD00013221
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24277691
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98%
• 형태: powder
• 색상: white to off-white
• solubility: H₂O: 50 mg/mL (solutions should be freshly prepared.); alcohol: insoluble
• 저장 온도: −20°C
• SMILES string: NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O
• InChI: 1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
• InChI key: FQPFAHBPWDRTLU-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

설명

애플리케이션

Aminophylline has been used:

• as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments
• as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts
• as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay

생화학적/생리학적 작용

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.

Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves