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Merck
모든 사진(1)

주요 문서

A4660

Sigma-Aldrich

6-Thioguanine

Hybri-Max, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

동의어(들):

2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol

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About This Item

실험식(Hill 표기법):
C5H5N5S
CAS Number:
Molecular Weight:
167.19
Beilstein:
157765
EC Number:
MDL number:
UNSPSC 코드:
12352207
PubChem Substance ID:
NACRES:
NA.75

생물학적 소스

synthetic (organic)

Quality Level

Grade

Hybri-Max

무균

γ-irradiated

제품 라인

BioXtra

분석

~98%

양식

lyophilized powder

농도

50 ×

기술

cell culture | hybridoma: suitable

불순물

endotoxin, tested

mp

≥300 °C (lit.)

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy

저장 온도

room temp

SMILES string

NC1=Nc2nc[nH]c2C(=S)N1

InChI

1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChI key

WYWHKKSPHMUBEB-UHFFFAOYSA-N

유전자 정보

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Used in hybridoma formation applications as a selection agent.

생화학적/생리학적 작용

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

재구성

Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 30 μM 2-amino-6-mercaptopurine.

법적 정보

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

픽토그램

Skull and crossbones

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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시험 성적서(COA)

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문서 라이브러리 방문

Donghui Li et al.
Nucleic acids research, 49(5), 2642-2654 (2021-02-17)
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
Nanne K H de Boer et al.
European journal of gastroenterology & hepatology, 17(4), 457-461 (2005-03-10)
The use of corticosteroids in autoimmune hepatitis is an established therapy. To avoid the possible serious side effects of corticosteroids, immunosuppression with azathioprine is often warranted. Azathioprine, a purine analogue, is frequently used to taper or replace corticosteroids. However, approximately
N K H de Boer et al.
Digestion, 73(1), 25-31 (2006-02-24)
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying
Mark Drost et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9403-9408 (2013-05-22)
In many individuals suspected of the common cancer predisposition Lynch syndrome, variants of unclear significance (VUS), rather than an obviously pathogenic mutations, are identified in one of the DNA mismatch repair (MMR) genes. The uncertainty of whether such VUS inactivate

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