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Merck
모든 사진(1)

Key Documents

A5111

Sigma-Aldrich

ABT-724 trihydrochloride

≥98% (HPLC)

동의어(들):

2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride

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About This Item

실험식(Hill 표기법):
C17H19N5 · 3HCl
CAS Number:
Molecular Weight:
402.75
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated

색상

white

solubility

H2O: >30 mg/mL

주관자

Abbott

저장 온도

2-8°C

SMILES string

Cl.Cl.Cl.C1CN(CCN1Cc2nc3ccccc3[nH]2)c4ccccn4

InChI

1S/C17H19N5.3ClH/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17;;;/h1-8H,9-13H2,(H,19,20);3*1H

InChI key

AZFUVPBLKQGSRI-UHFFFAOYSA-N

애플리케이션

ABT-724 is a dopamine D4 receptor agonist. ABT-724 has been used in the study of impulsive behavior and penile erection in rats.

특징 및 장점

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Mikhail N Koffarnus et al.
Behavioural pharmacology, 22(4), 300-311 (2011-06-23)
Impulsivity is widely regarded as a multidimensional trait that encompasses two or more distinct patterns of behavior, and dopaminergic systems are implicated in the expression of impulsive behavior in both humans and animal subjects. Impulsive choice, or the tendency to
Ronan Depoortère et al.
Behavioural pharmacology, 20(4), 303-311 (2009-07-09)
Dopamine (DA) is implicated in penile erection (PE) and yawning (YA) in rats through activation of D2-like receptors. However, the exact role of each subtype (D2, D3 and D4) of this receptor family in PE/YA is still not clearly elucidated.
Danuta Marona-Lewicka et al.
Psychopharmacology, 203(2), 265-277 (2008-07-08)
Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. The present study sought to characterize the effects of several dopamine D(4) agonists

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