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A8346

Sigma-Aldrich

ProteoMass™ ACTH Fragment 18-39 MALDI-MS Standard

vial of 10 nmol, monoisotopic mol wt 2,464.1989 Da

동의어(들):

Adrenocorticotropic hormone fragment 18-39

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About This Item

CAS Number:
53917-42-3
MDL number:
MFCD00076159
UNSPSC 코드:
41116107
PubChem Substance ID:
24891334
NACRES:
NA.24

분자량

monoisotopic mol wt 2,464.1989 Da

Quality Level

100

포장

vial of 10 nmol

SMILES string

CC(C)CC(NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(Cc4ccc(O)cc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(C)C)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(Cc6ccccc6)C(O)=O

InChI

1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)

InChI key

ZYDMZKPAPSZILB-UHFFFAOYSA-N

Amino Acid Sequence

Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

일반 설명

The single peptide or protein standard is used to calibrate and test matrix assisted laser desorption ionization (MALDI) mass spectrometers. Adrenocorticotropic hormone (ACTH) is synthesized from its precursor pro-opiomelanocortin (POMC). It is released from anterior pituitary gland in response to corticotropin-releasing hormone (CRH) from hypothalamus.

애플리케이션

Peptide calibration standard for MALDI-MS instruments; 1 vial contains 10 nmols.
ProteoMass™ ACTH fragment 18-39 MALDI-MS standard has been used as a peptide calibration standard for matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) instruments.

생화학적/생리학적 작용

Adrenocorticotropic hormone (ACTH) stimulates the synthesis and release of glucocorticoids and androgens through cAMP-dependent by a G-protein coupled receptor in adrenal gland. Overproduction of ACTH leads to marked skin pigmentation.

저장 및 안정성

Each standard is stored at room temperature and is shipped at ambient temperature. Standard stock solutions can be frozen in aliquots, but should not be subjected to more than 3 freeze-thaw cycles. Standard solutions are recommended for use for no longer than one month after reconstitution.

법적 정보

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

관련 제품

제품 번호
설명
가격

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
SLCP9239
0000255768
SLCH1511
SLCG6611
SLCC7474

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문서 라이브러리 방문

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Salivary peptidome profiling for diagnosis of severe early childhood caries.
Sun X, et al.
Journal of Translational Medicine, 14(1), 240-240 (2016)
D Vieau et al.
The Journal of clinical endocrinology and metabolism, 79(5), 1503-1506 (1994-11-01)
POMC processing is frequently altered in ACTH-secreting nonpituitary tumors in which intermediate lobe-like peptides such as corticotropin-like intermediate lobe peptide (CLIP) are occasionally generated. In rodent pituitaries, the exclusive presence of prohormone convertase PC2 in the melanotrophs of the intermediate
Jessica L Costa et al.
General and comparative endocrinology, 136(1), 12-16 (2004-02-26)
alpha-Melanocyte stimulating hormone (MSH) and adrenocorticotropin (ACTH)1-24, the minimal ACTH sequence required for full activity, differ only by the 10 C-terminal amino acids of ACTH1-24. Interestingly, these ten C-terminal residues have been highly conserved throughout vertebrate evolution. To understand the
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문서

Ultra-Pure MALDI Matrices

One of the most important aspects of our ultra-pure MALDI matrix substances is their ability to dissolve rapidly and completely; a brief vortex mixing is typically sufficient.

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