추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to off-white
solubility
H2O: slightly soluble <0.28 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.77 mg/mL
DMSO: ~16 mg/mL at 60 °C
0.1 M NaOH: soluble
SMILES string
CN1C(=O)N(C)c2nc([nH]c2C1=O)C3CCCC3
InChI
1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14)
InChI key
SCVHFRLUNIOSGI-UHFFFAOYSA-N
유전자 정보
human ... ADORA1(134)
생화학적/생리학적 작용
Selective A1 adenosine receptor antagonist.
특징 및 장점
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
Elizabeth Shephard et al.
Cortex; a journal devoted to the study of the nervous system and behavior, 117, 96-110 (2019-04-08)
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are common and impairing neurodevelopmental disorders that frequently co-occur. The neurobiological mechanisms involved in ASD and ADHD are not fully understood. However, alterations in large-scale neural networks have been proposed as core
Ines Schmidts et al.
Nucleic acids research, 44(17), 8261-8271 (2016-06-30)
Small interfering RNAs (siRNAs) defend the organism against harmful transcripts from exogenous (e.g. viral) or endogenous (e.g. transposons) sources. Recent publications describe the production of siRNAs induced by DNA double-strand breaks (DSB) in Neurospora crassa, Arabidopsis thaliana, Drosophila melanogaster and
Huihui Chen et al.
Nature communications, 9(1), 3209-3209 (2018-08-12)
Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient
Harald Schuhwerk et al.
Nucleic acids research, 45(19), 11174-11192 (2017-10-05)
One of the fastest cellular responses to genotoxic stress is the formation of poly(ADP-ribose) polymers (PAR) by poly(ADP-ribose)polymerase 1 (PARP1, or ARTD1). PARP1 and its enzymatic product PAR regulate diverse biological processes, such as DNA repair, chromatin remodeling, transcription and
Hiro Sato et al.
Nature communications, 8(1), 1751-1751 (2017-11-25)
Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in cancer. A DNA double-strand break (DSB) is the most critical type of genotoxic stress, but the involvement of DSB repair in PD-L1 expression has not been investigated. Here we
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