P8761

Probenecid

≥98% (NaOH, titration), powder, uricosuric agent

• Synonym(s): p-(Dipropylsulfamoyl)benzoic acid
• Empirical Formula (Hill Notation): C₁₃H₁₉NO₄S
• CAS Number: 57-66-9
• Molecular Weight: 285.36
• EC Number: 200-344-3
• MDL number: MFCD00038402
• UNSPSC Code: 12161501
• PubChem Substance ID: 24898976
• NACRES: NA.77

Properties

• assay: ≥98% (NaOH, titration)
• Quality Level: 200
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES string: CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
• InChI: 1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
• InChI key: DBABZHXKTCFAPX-UHFFFAOYSA-N
• Gene Information: human ... SLC22A11(55867) , SLC22A6(9356) , SLC22A8(9376)

Description

Application

Probenecid has been used:

• as a component of phenol red free Hank′s buffer for Intracellular Ca²⁺-mobilization assay
• as a component of calcium sensitive dye for calcium mobilization Studies
• as a supplement in Hank′s balanced salt solution (HBSS) assay buffer

Useful as an inhibitor of the organic anion transporter, MRP.

Biochem/physiol Actions

Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves