추천 제품
양식
powder
Quality Level
저장 온도
2-8°C
SMILES string
CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N
InChI
1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
InChI key
TVZCRIROJQEVOT-CABCVRRESA-N
유전자 정보
rat ... Kcna1(24520) , Kcnj1(24521) , Kcnj5(29713) , Kcnj8(25472)
애플리케이션
Cromakalim has been used:
- as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
- as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
- as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.
생화학적/생리학적 작용
Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.
특징 및 장점
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
E Grana et al.
European journal of pharmacology, 319(1), 57-64 (1997-01-14)
The present study was carried out to look at the influence of the K+ channel opener cromakalim, compared with suramin and prazosin, on the contractile response evoked by single-pulse field stimulation and exogenous agonists in epididymal and prostatic portions of
BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle
Sanguinetti M C, et al.
Proceedings of the National Academy of Sciences, 85(21), 8360-8364 (1988)
W Spinelli et al.
European journal of pharmacology, 179(3), 243-252 (1990-04-25)
The cardiac electrophysiologic effects of the potassium channel activators cromakalim, pinacidil and nicorandil were determined in anesthetized open-chest normotensive dogs using conventional surface electrogram recording techniques. Intravenous administration of cromakalim (0.025-0.5 mg/kg), pinacidil (0.1-2.0 mg/kg) and nicorandil (0.1-2.5 mg/kg) produced
Xavier Florence et al.
Bioorganic & medicinal chemistry, 19(13), 3919-3928 (2011-06-15)
The synthesis of different series of 4- and 6-substituted R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans is described. All of these new benzopyran derivatives were bearing, at the 4-position, a phenylthiourea moiety substituted on the phenyl ring by a meta or a para-electron-withdrawing group such as
Cromakalim blocks the purinergic response evoked in rat vas deferens by single-pulse electrical stimulation
Grana E, et al.
European Journal of Pharmacology, 319(1), 57-64 (1997)
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