H9523

Serotonin hydrochloride

≥98%, powder, neurotransmitter

• 동의어(들): 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
• 실험식(Hill 표기법): C₁₀H₁₂N₂O · HCl
• CAS Number: 153-98-0
• Molecular Weight: 212.68
• Beilstein: 3570963
• MDL number: MFCD00012686
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278124
• NACRES: NA.77

속성

• product name: Serotonin hydrochloride, powder
• 분석: ≥98%
• Quality Level: 200
• 형태: powder
• 색상: white to off-white
• mp: 149-154 °C (lit.)
• solubility: H₂O: 17 mg/mL; 0.1 M HCl: 22 mg/mL; ethanol: 5.3 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cl[H].NCCc1c[nH]c2ccc(O)cc12
• InChI: 1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
• InChI key: MDIGAZPGKJFIAH-UHFFFAOYSA-N
• 유전자 정보: human ... HTR3A(3359)

설명

일반 설명

Serotonin is a ubiquitous molecule found in all animals. It shows diverse effects in the central and peripheral nervous system (CAN/PNS). Serotonin acts as a hormone and as a mitogen. It is produced in the axon terminal present in the brain. Action potential induces the release of serotonin that diffuses across the synapse to turn on the post-synaptic receptors. Serotonin plays a crucialrole in development, respiration, thermoregulation, endocrine, cardiovascular, and gastrointestinal functions. It also plays a role in sensory perceptional behaviors such as the sleep-wake cycle, sex, mood, memory, aggression, pain sensitivity, learning, and cognition. Serotonin impacts several psychiatric disorders such as schizophrenia, anorexia nervosa, depression, and a range of anxiety disorders such as obsessive-compulsive disorder, panic attacks, and social phobia. Variations in serotonin levels are associated withimpulse-related disorders or personalities like substance abuse, gambling, attention deficit disorder, obsessive-control, and aggression.

애플리케이션

Serotonin hydrochloride hasbeen used: to study the mechanisms of 5-hydroxytryptamine receptor antagonistsregulate fibrosis in liver spheroids, to study its effects on theextracellular-related-kinase (ERK) phosphorylation in human embryonic kidneycells, in transwell assay, wound healing assay and tumor allograft assay incolon carcinoma cell line

생화학적/생리학적 작용

Neurotransmitter.

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

Solutions should be freshly prepared.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H361
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves