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Merck
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주요 문서

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B3259

Sigma-Aldrich

Bradykinin acetate salt

powder, ≥98% (HPLC)

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About This Item

실험식(Hill 표기법):
C50H73N15O11 · xC2H4O2
CAS Number:
6846-03-3
Molecular Weight:
1060.21 (free base basis)
EC Number:
227-781-2
UNSPSC 코드:
12352106
NACRES:
NA.32

Quality Level

100

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated

색상

white

solubility

0.1 M acetic acid: 25 mg/mL, clear, colorless

UniProt 수납 번호

P01042

저장 온도

−20°C

InChI

1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

InChI key

QXZGBUJJYSLZLT-FDISYFBBSA-N

유전자 정보

human ... KNG1 (includes EG:3827)

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Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

애플리케이션

Bradykinin acetate salt has been used:
  • to stimulate the contraction of guinea pig ileum
  • as a contractile agent in fibroblasts
  • In the stimulation of endothelium of human subcutaneous artery
  • To evoke Ca2+ signals in neuroblastoma-glioma hybrid cell line, NG108-15

생화학적/생리학적 작용

Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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