A9650

Angiotensin I human acetate salt hydrate

≥90% (HPLC), powder, suitable for mammalian cell culture

• 동의어(들): 5-Ile-angiotensin I, 5-Isoleucine-angiotensin I, Pepsitensin, Proangiotensin, Hypertensin I
• 실험식(Hill 표기법): C₆₂H₈₉N₁₇O₁₄ · xC₂H₄O₂ · yH₂O
• CAS Number: 70937-97-2
• Molecular Weight: 1296.48 (anhydrous free base basis)
• MDL number: MFCD00133091
• UNSPSC 코드: 12352202
• eCl@ss: 42020611
• PubChem Substance ID: 24891483
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 분석: ≥90% (HPLC)
• 형태: powder
• 분자량: 1296 Da by calculation (Average Mass)
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place)
• 기술: cell culture | mammalian: suitable
• solubility: acetic acid: 25 mg/mL, clear, colorless
• UniProt 수납 번호: P01019
• 저장 온도: −20°C
• SMILES string: CC(O)=O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(O)=O
• InChI: 1S/C62H89N17O14.2C2H4O2/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3;2*1-2(3)4/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68);2*1H3,(H,3,4)/t35-,41-,42-,43-,44-,45+,46-,47-,48-,50-,51-;;/m0../s1
• InChI key: CKIFOTYDIFUKEP-AUVUXLIHSA-N
• 유전자 정보: human ... AGT(183)

설명

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

일반 설명

Angiotensinogen (Angiotensin I) is a renin substrate, which is produced by the liver.

Research area: Cell Signaling

애플리케이션

Angiotensin I human acetate salt hydrate has been used:

• as an external calibration standard, it was applied to α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB) matrix,
• to prepare angiotensin I solution gravimetrically for hydrolysis and also used as a model peptide to demonstrate SI (système international) -traceable amino acid analysis
• as an analyte to deposit on the target in the study of on-line single droplet deposition for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry

생화학적/생리학적 작용

Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.

Angiotensin is a component of the renin-angiotensin aldosterone system (RAAS). This hormonal circulating system aids in regulating blood pressure by modulating potassium secretion, vascular tone, and sodium and water reabsorption. RAAS also participates in fibrosis, apoptosis, and inflammation.

항체 흡착제

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH.2CH₃COOH.6H₂O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)