추천 제품
생물학적 소스
synthetic (organic)
분석
≥99% (TLC)
형태
powder
색상
white
solubility
ethanol: 10 mg/mL
저장 온도
2-8°C
SMILES string
Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
ZNRYCIVTNLZOGI-UHFFFAOYSA-N
유전자 정보
human ... SLC2A1(6513) , SLC2A4(6517)
애플리케이션
ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.
생화학적/생리학적 작용
ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.
특징 및 장점
This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
M Saitoh et al.
The Journal of biological chemistry, 262(16), 7796-7801 (1987-06-05)
Systematically synthesized derivatives of ML-9, 1-(5-chloronaphthalenesulfonyl)-1H-hexahydro-1,4-diazepine, were found to inhibit both Ca2+-calmodulin-dependent and -independent smooth muscle myosin light chain kinases with a similar concentration dependence, and their inhibitions were of the competitive type with respect to ATP. Moreover, ML-9 as
Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death
Kondratskyi A, et al.
Cell Death & Disease, 5(4), e1193-e1193 (2014)
A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes
Honjo M, et al.
Experimental Eye Research, 75(2), 135-142 (2002)
Letitia Weigand et al.
American journal of physiology. Lung cellular and molecular physiology, 290(2), L284-L290 (2005-09-13)
Endothelin-1 (ET-1), a potent vasoconstrictor, is believed to contribute to the pathogenesis of hypoxic pulmonary hypertension. Previously we demonstrated that contraction induced by ET-1 in intrapulmonary arteries (IPA) from chronically hypoxic (CH) rats occurred independently of changes in intracellular Ca2+
RhoD inhibits RhoC-ROCK-dependent cell contraction via PAK6
Durkin CH, et al.
Developmental Cell, 41(3), 315-329 (2017)
문서
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
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