C130
Chloro-APB hydrobromide
solid
동의어(들):
(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C19H20ClNO2 · HBr
CAS Number:
Molecular Weight:
410.73
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
형태
solid
Quality Level
색상
tan
solubility
H2O: 3.7 mg/mL
aqueous base: unstable
ethanol: soluble
저장 온도
2-8°C
SMILES string
Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3
InChI
1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
InChI key
WLXGFAVTAAQOFH-UHFFFAOYSA-N
유전자 정보
human ... DRD1(1812)
애플리케이션
Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.
생화학적/생리학적 작용
Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.
주의사항
Light sensitive
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Thomas F Tropea et al.
Biological psychiatry, 63(11), 1066-1074 (2008-02-16)
Prenatal exposure to cocaine can impede normal brain development, triggering a range of neuroanatomical and behavioral anomalies that are evident throughout life. Mouse models have been especially helpful in delineating neuro-teratogenic consequences after prenatal exposure to cocaine. The present study
Jennifer L Cornish et al.
Journal of psychopharmacology (Oxford, England), 22(1), 100-110 (2008-01-12)
Methamphetamine is a drug that is often consumed at dance parties or nightclubs where the ambient temperature is high. The present study determined whether such high ambient temperatures alter intravenous methamphetamine self-administration in the rat. Male Hooded Wistar rats were
Chinwe A Nwaneshiudu et al.
Neuropharmacology, 57(3), 295-301 (2009-06-09)
Acute activation or blockade of neurokinin-3 (NK-3) receptors has been shown to alter dopamine-mediated function and behaviors, however long-term effects of NK-3 receptor blockade remain largely unknown. The present study investigated whether acute and repeated administration of the NK-3 receptor
K D Carr et al.
Neuroscience, 165(4), 1074-1086 (2009-11-26)
Previous findings suggest that neuroadaptations downstream of D-1 dopamine (DA) receptor stimulation in nucleus accumbens (NAc) are involved in the enhancement of drug reward by chronic food restriction (FR). Given the high co-expression of D-1 and GluR1 AMPA receptors in
Thomas P Giordano et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(50), 17051-17062 (2010-12-17)
L-type Ca(2+) channel (LTCC)-activated signaling cascades contribute significantly to psychostimulant-induced locomotor sensitization; however, the precise contribution of the two brain-specific subunits Ca(v)1.2 and Ca(v)1.3 remains mostly unknown. In this study, by using amphetamine and cocaine locomotor sensitization in mutant mice
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