D054
R(+)-SCH-23390 hydrochloride
≥98% (HPLC), solid
동의어(들):
R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C17H18ClNO · HCl
CAS Number:
Molecular Weight:
324.24
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
형태
solid
광학 활성
[α]/D +32.1°, c = 1 in DMF(lit.)
저장 조건
desiccated
protect from light
색상
white
solubility
H2O: >5 mg/mL
SMILES string
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
유전자 정보
human ... DRD1(1812)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
R(+)-SCH-23390 hydrochloride has been used:
- for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
- as a D1 receptor-selective antagonist for intracranial drug infusions
- as an antagonist of D1 receptor to study its effect on learning ability in fish
생화학적/생리학적 작용
R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.
특징 및 장점
This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
법적 정보
Sold with the permission of Schering-Plough.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
Messias Joao PM, et al.
Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. Royal Society (Great Britain), 283(1823), 20152272-20152272 (2016)
L C Iorio et al.
The Journal of pharmacology and experimental therapeutics, 226(2), 462-468 (1983-08-01)
SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in
A Sidhu et al.
European journal of pharmacology, 128(3), 213-220 (1986-09-09)
[125I]SCH 23982, [125I]8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol, binds reversibly and with high affinity (Kd = 0.7 +/- 0.05 nM) to specific binding sites (maximum binding = 108 +/- 3.5 fmol/mg) in the caudate nucleus of the rat brain. The caudate binding site displays pharmacological
SCH 23390: the first selective dopamine D1-like receptor antagonist
Bourne James A
Cns Drug Reviews, 7(4), 399-414 (2001)
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Meririnne E, et al.
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
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