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Merck
모든 사진(2)

주요 문서

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C141

Sigma-Aldrich

CGS-21680 hydrochloride hydrate

solid

동의어(들):

2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride hydrate

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C23H29N7O6 · HCl · xH2O
CAS Number:
124182-57-6
Molecular Weight:
535.98 (anhydrous basis)
MDL number:
MFCD11045878
UNSPSC 코드:
12352200
PubChem Substance ID:
24277698
NACRES:
NA.77

분석

≥98% (HPLC)

Quality Level

100

형태

solid

저장 조건

desiccated

색상

white

solubility

DMSO: >10 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL

저장 온도

−20°C

SMILES string

O.Cl.CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(NCCc4ccc(CCC(O)=O)cc4)nc23

InChI

1S/C23H29N7O6.ClH.H2O/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H;1H2/t16-,17+,18-,22+;;/m0../s1

InChI key

VIRPCGAECNOLOO-VBQNEDDFSA-N

유전자 정보

human ... ADORA2A(135) , ADORA2B(136)

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생화학적/생리학적 작용

Adenosine receptor agonist, which possesses selectivity for A2 verses A1 receptors.

주의사항

Hygroscopic

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Patrycja Koszalka et al.
International journal of molecular sciences, 23(10) (2022-05-29)
The accumulation of specific metabolic intermediates is known to promote cancer progression. We analyzed the role of 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR), a nucleotide metabolite that accumulates in the blood of cancer patients, using the 4T1 murine in vivo breast cancer model, and
Seema Gulyani et al.
Experimental neurology, 215(2), 236-242 (2008-11-18)
Brain iron insufficiency has been implicated in several neurological disorders. The dopamine system is consistently altered in studies of iron deficiency in rodent models. Changes in striatal dopamine D(2) receptors are directly proportional to the degree of iron deficiency. In
M F Jarvis et al.
The Journal of pharmacology and experimental therapeutics, 251(3), 888-893 (1989-12-01)
Characterization of the adenosine A2 receptor has been limited due to the lack of available ligands which have high affinity and selectivity for this adenosine receptor subtype. In the present study, the binding of a highly A2-selective agonist radioligand, [3H]CGS
Liu Yang et al.
Pediatric research (2022-02-28)
Reducing neuroinflammatory damage is an effective strategy for treating white-matter damage (WMD) in premature infants. Caffeine can ameliorate hypoxia-ischemia-induced brain WMD; however, its neuroprotective effect and mechanism against hypoxic-ischemic WMD remain unclear. We used 3-day-old Sprague-Dawley rats to establish a
J W Phillis
Brain research, 509(2), 328-330 (1990-02-19)
The A2 selective adenosine receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) depressed the spontaneous, acetylcholine- and glutamate-evoked firing of rat cerebral sensorimotor cortical neurons. Iontophoretically applied CGS 21680 was equipotent with adenosine as a depressant and its actions were antagonized by 8-p-sulphophenyltheophylline
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