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Merck
모든 사진(1)

문서

C1619

Sigma-Aldrich

CGS-9343B

≥98% (HPLC), powder

동의어(들):

1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]- benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate, CGS9343B, KW-5617, Zaldaride maleate

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C26H28N4O2 · C4H4O4
CAS Number:
109826-27-9
Molecular Weight:
544.60
MDL number:
MFCD04113002
UNSPSC 코드:
12352200
PubChem Substance ID:
329774899
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

powder

색상

white to off-white

solubility

DMSO: >10 mg/mL

주관자

Novartis

저장 온도

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.CC4(CN1CCC(CC1)N2C(=O)Nc3ccccc23)OCc5ccccc5-n6cccc46

InChI

1S/C26H28N4O2.C4H4O4/c1-26(24-11-6-14-29(24)22-9-4-2-7-19(22)17-32-26)18-28-15-12-20(13-16-28)30-23-10-5-3-8-21(23)27-25(30)31;5-3(6)1-2-4(7)8/h2-11,14,20H,12-13,15-18H2,1H3,(H,27,31);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

NGODOSILXOFQPH-BTJKTKAUSA-N

생화학적/생리학적 작용

CGS-9343B is a selective calmodulin antagonist with minimal protein kinase C or antidopaminergic activity. CGS-9343B is a potent inhibitor of calmodulin-activated (Type I) phosphodiesterase activity with IC50 in the nanomolar range.

특징 및 장점

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

N Aikawa et al.
Japanese journal of pharmacology, 83(1), 86-88 (2000-07-11)
The effect of zaldaride maleate (ZAL) on intracellular Ca2+-mediated short-circuit current (Isc) response in rat colonic mucosa was investigated. The Isc response to acetylcholine was partially reduced by the neuronal blocker tetrodotoxin. The tetrodotoxin-sensitive Isc response to acetylcholine was inhibited
L Glass-Marmor et al.
European journal of pharmacology, 328(2-3), 241-248 (1997-06-11)
Glycolysis, which is the primary energy source in cancer cells, is known to be controlled by allosteric regulators, as well as by reversible binding of glycolytic enzymes to cytoskeleton. We have previously found that different calmodulin antagonists decrease the levels
N Aikawa et al.
Japanese journal of pharmacology, 83(3), 269-272 (2000-08-22)
The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin E2 (dmPGE2)-induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE2-induced increase in water content in the colon, but not that in the small intestine. In the colonic
Lu Li et al.
The Journal of biological chemistry, 278(2), 1195-1200 (2002-11-07)
The steroid hormone estrogen elicits biological effects in cells by binding to and activating the estrogen receptor (ER). Estrogen binding induces a conformational change in the receptor, inducing nuclear translocation and transcriptional activation of ER. The ubiquitous Ca(2+)-binding protein calmodulin
Nina Westphal et al.
Scientific reports, 7(1), 8622-8622 (2017-08-19)
Polysialic acid (PSA) and its major protein carrier, the neural cell adhesion molecule NCAM, play important roles in many nervous system functions during development and in adulthood. Here, we show that a PSA-carrying NCAM fragment is generated at the plasma
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