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Merck
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주요 문서

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C2506

Sigma-Aldrich

Cytochrome c from equine heart

≥95% (SDS-PAGE)

동의어(들):

Cytochrome c from horse heart

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모든 사진(8)

About This Item

CAS Number:
9007-43-6
EC Number:
232-700-9
MDL number:
MFCD00130890
UNSPSC 코드:
12352202
NACRES:
NA.61

생물학적 소스

horse heart

Quality Level

300

분석

≥95% (SDS-PAGE)

형태

powder

분자량

12,384

기술

cell based assay: suitable

solubility

H2O: soluble 10 mg/mL

적합성

suitable for molecular biology

UniProt 수납 번호

P00004

응용 분야

cell analysis

저장 온도

−20°C

유전자 정보

horse ... CYCS(100053958)

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애플리케이션

Cytochrome c has been used:
  • in the reduction of ferricytochrome c by xanthine oxidase-generated superoxide radicals
  • as an analyte by the single droplet deposition method using MALDI mass spectra
  • as a terminal electron acceptor in the assay of standard cytochrome c reductase activity
  • in cytochrome c oxidase histochemistry
  • in the measurement of cytochrome C oxidase activity
  • as a component of phosphate buffer for the detection and evaluation of complex IV activity using blue-native gel electrophoresis (BN-PAGE)
  • for detection of extracellular superoxide anion (ECSA) in isolated kidney phagocytes
The specific sites and extent of oxidation in horse cytochrome c treated with H2O2 and UV were characterized. It was suggested that the state of these sites could be used as a biomarker for the oxidative environment in a cell.

생화학적/생리학적 작용

Cytochrome c, released from the outer mitochondrial compartment into the cytosol aids in activation of caspase-9 and initiation of the apoptotic protease cascade. This process is facilitated through its interaction with apoptotic protease-activating factor-1 (APAF-1) and deoxyadenosine triphosphate (dATP).(3) Various studies suggest that measurement of cytochrome C level in serum of tumor patients can be considered as a potential marker for cell death in vivo.
Cytochrome c is primarily known as an electron-carrying mitochondrial protein. The transition of cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen

제조 메모

Prepared using TCA.
This product in solution should be dark red to reddish brown when dissolved in water at 10 mg/mL.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Enzyme-catalyzed free radical reactions with nicotinamide adenine nucleotides. II. Lactate dehydrogenase-catalyzed oxidation of reduced nicotinamide adenine dinucleotide by superoxide radicals generated by xanthine oxidase.
P C Chan et al.
The Journal of biological chemistry, 249(4), 1317-1319 (1974-02-25)
A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction
Warnsmann V, et al.
Mechanisms of Ageing and Development, 170, 45-58 (2018)
B C Hill
The Journal of biological chemistry, 266(4), 2219-2226 (1991-02-05)
The reaction of the electrostatic cytochrome c-cytochrome oxidase complex with oxygen is measured by transient absorption spectroscopy. The oxygen reaction is initiated by photolytic removal of CO from cytochrome oxidase, using a flash-pumped dye laser. The subsequent reaction of the
Vittorio Pandini et al.
The Journal of biological chemistry, 277(50), 48463-48471 (2002-10-09)
Toxoplasma gondii possesses an apicoplast-localized, plant-type ferredoxin-NADP(+) reductase. We have cloned a [2Fe-2S] ferredoxin from the same parasite to investigate the interplay of the two redox proteins. A detailed characterization of the two purified recombinant proteins, particularly as to their
?-1,3 glucan derived from Euglena gracilis and Algamune? enhances innate immune responses of red drum (Sciaenops ocellatus L.)
Yamamoto FY, et al.
Fish & Shellfish Immunology, 77, 273-279 (2018)
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