C2920

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

≥98% (TLC), powder, Mitophagy inducer

• 동의어(들): FCCP, Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone
• Linear Formula: CF₃OC₆H₄NHN=C(CN)₂
• CAS Number: 370-86-5
• Molecular Weight: 254.17
• Beilstein: 664446
• EC Number: 206-730-8
• MDL number: MFCD00009699
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24892549
• NACRES: NA.77

속성

• product name: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, ≥98% (TLC), powder
• Quality Level: 300
• 분석: ≥98% (TLC)
• 형태: powder
• 색상: yellow
• mp: 174-175 °C (dec.) (lit.)
• solubility: 95% ethanol: soluble
• 저장 온도: 2-8°C
• SMILES string: FC(F)(F)Oc1ccc(N\N=C(/C#N)C#N)cc1
• InChI: 1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
• InChI key: BMZRVOVNUMQTIN-UHFFFAOYSA-N

설명

일반 설명

FCCP is a protonophore (H+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. It is capable of depolarizing plasma and mitochondrial membranes. FCCP has been shown to have several effects on cellular calcium. It is also reported to inhibit a background K⁺ current and induce a small inward current, reduce pH by 0.1 unit, and induce a rise of intracellular [Na⁺]. FCCP stimulates Mg²⁺-ATPase activity, inhibits β-amyloid production, and mimics the effect of selective glutamate agonist N-methyl-D-aspartate (NMDA) on mitochondrial superoxide production.

애플리케이션

Carbonylcyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) has been used as an uncouplerin cell culture: to study its effects on murine thermogenic adipocytes, tostudy its effects on β-oxidation in mouse mitochondria, to study its effects on the metabolism in bone marrow-derived dendriticcells from mouse

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H314,H317,H413
• 예방조치 성명서: P260 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges