추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
15B8, monoclonal
분자량
antigen 94 kDa
종 반응성
chicken, bovine, human, canine
기술
immunocytochemistry: suitable
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:1000 using cultured MDBK cells
microarray: suitable
western blot: 1:1000 using cultured MDBK cells extract
동형
IgG1
UniProt 수납 번호
응용 분야
research pathology
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CTNNB1(1499)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Monoclonal Anti-β-Catenin (mouse IgG1 isotype) is derived from the 15B8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. β-catenin belongs to the armadillo family and comprises the N-terminal region with 12 imperfect repeats and a conserved C-terminal region. The locus 3p22.1 in the human chromosome harbors β-catenin gene. β-catenin shares 70% sequence identity to a protein encoded by Drosophila armadillo, a segment polarity gene. Both armadillo and β-catenin share considerable homology with plakoglobin, which has been proposed to be γ-catenin.
특이성
Recognizes specifically mammalian and avian β-catenin. Does not cross-react with plakoglobin (γ-catenin).
면역원
recombinant chicken β-catenin.
애플리케이션
Monoclonal Anti-β-Catenin antibody produced in mouse has been used:
- immunoblotting
- immunohistochemistry
- immunolabeling
- immunofluorescence
- immunocytochemical staining
생화학적/생리학적 작용
β-catenin is a prime component of the wingless (Wnt) pathway and plays a key role in gene expression during development. The homology between β-catenin and armadillo raised the possibility that β-catenin has a developmental signaling role in vertebrates. β-catenin mediates the interaction of the E-cadherin-catenin complex with the epidermal growth factor (EGF) receptor. β-catenin and plakoglobin are substrates for tyrosine phosphorylation following EGF stimulation of cells. β-catenin also associates with the tumor suppressor protein adenomatous polyposis coli (APC). Monoclonal antibody reacting specifically with β-catenin is an essential tool in defining the interactions and distributions of β-catenin and its relationships with other catenins and cadherins in various cells and tissues.
물리적 형태
The product is provided as ascites fluid with 0.1% sodium azide as a preservative.
저장 및 안정성
For extended storage freeze in working aliquots. For continuous use, store at 2-8 °C for up to one month. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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시험 성적서(COA)
Lot/Batch Number
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