T6277

Monoclonal Anti-Troponin T antibody produced in mouse

clone JLT-12, ascites fluid

• 동의어(들): Anti-ANM, Anti-NEM5, Anti-STNT, Anti-TNT, Anti-TNTS
• MDL number: MFCD00164752
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: JLT-12, monoclonal
• 포함: 15 mM sodium azide
• 종 반응성: chicken, rat, bovine, rabbit
• 기술: immunohistochemistry: suitable; western blot: 1:200 using rabbit total skeletal muscle extract
• 동형: IgG1
• UniProt 수납 번호: P13805
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: rat ... Tnnt1(171409) , Tnnt2(24837) , Tnnt3(24838)

설명

일반 설명

Monoclonal Anti-Troponin T (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Troponin T is a vital subunit of troponin. Troponin T is a comma or rod shaped protein with a length of 185-205 Å. Troponin T is positioned in the actin helix groove and is extended along the filament of troponin. Life span of serum troponin T is 120 minutes. N- terminal end of the protein is enriched in negatively charged residues and C- terminal end is enriched with positively charged residues. This uneven distribution of charges in troponin T facilitates its aggregation at physiological salt concentration. In humans, cardiac troponin T exists in four isoforms, out of which three are expressed in the fetus and one isoform is expressed in the adult heart.

면역원

Troponin T from rabbit skeletal muscle.

애플리케이션

Monoclonal Anti-Troponin T antibody produced in mouse has been used in following studies:

• Western blot analysis.
• Immunocytochemical analysis.
• Immunofluorescence.

Monoclonal Anti-Troponin T antibody produced in mouse has been used in immunostaining.

생화학적/생리학적 작용

Troponin T is a subunit of troponin, which facilitates binding of troponin to tropomyosin. It also plays a crucial role in muscle contraction. Cardiac troponin T acts as a potential marker for the detection of acute myocardial infarction (MI). Apart from facilitating binding of troponin components to the actin-tropomyosin filament, it is has an essential role in the regulation of actomyosin ATPase activity. Cardiac troponin T gene mutation leads to hypertrophic cardiomyopathy.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable