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Merck
모든 사진(3)

Key Documents

SAB4200717

Sigma-Aldrich

Anti-Troponin T antibody, Mouse monoclonal

clone JLT-12, purified from hybridoma cell culture

동의어(들):

Anti-TNNT1, Anti-TNNT2

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

항체 형태

purified from hybridoma cell culture

항체 생산 유형

primary antibodies

클론

JLT-12, monoclonal

형태

buffered aqueous solution

분자량

antigen ~38 kDa

종 반응성

rat, human, mouse, bovine, rabbit, goat

농도

~1.0 mg/mL

기술

immunoblotting: 0.5-1 μg/mL using rat skeletal muscle extract
immunofluorescence: suitable
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human skeletal muscle sections

동형

IgG1

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... TNNT1(7138)

일반 설명

Anti-Troponin T antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the JLT-12 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with purified Troponin T from rabbit skeletal muscle. Troponin T (TNNT) is the tropomyosin binding subunit of the troponin complex. Three genes have evolved to encode the cardiac (TNNT2), slow (TNNT1) and fast (TNNT3) skeletal muscle Troponin T proteins, which are specifically expressed in cardial, slow and fast skeletal muscles, respectively.

면역원

purified Troponin T from rabbit skeletal muscle

애플리케이션

  • Anti-Troponin T antibody, Mouse monoclonal has been used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

생화학적/생리학적 작용

Troponin T (TNNT) participates in calcium regulation of actin thin filament function and is required for the contraction of striated muscles. Levels of cardiac Troponin T serve as a sensitive biomarker of myocardial injury. Troponin T has also been suggested as a potential marker in diagnosis of skeletal myopathies including amyotrophic lateral sclerosis (ALS).

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

The troponin complex and regulation of muscle contraction
Farah CS, et al.
Faseb Journal, 9(9), 755-767 (1995)
Elevation of cardiac troponin T in patients with amyotrophic lateral sclerosis
Mach L, et al.
Acta Neurologica Belgica, 116(4) (2016)
Cardiac troponin T and fast skeletal muscle denervation in ageing
Xu Z, et al.
Journal of Cachexia, Sarcopenia and Muscle, 8(5), 808-808 (2017)
Amyotrophic lateral sclerosis (ALS), a novel rare cause of elevated plasma troponin T levels
Von LTG, et al.
Clinical Laboratory (2011)
TNNT1, TNNT2, and TNNT3: Isoform Genes, Regulation, and Structure-Function Relationships.
Wei B and Jin J P
Gene, 582(1), 1-13 (2016)

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