C7861

Citalopram hydrobromide

≥98% (HPLC), powder, serotonin uptake inhibitor

• 동의어(들): 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
• 실험식(Hill 표기법): C₂₀H₂₁FN₂O · HBr
• CAS Number: 59729-32-7
• Molecular Weight: 405.30
• EC Number: 261-890-6
• MDL number: MFCD02101306
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278335
• NACRES: NA.77

속성

• 제품명: Citalopram hydrobromide, ≥98% (HPLC)
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• solubility: chloroform: soluble; methanol: soluble
• 주관자: Forest Labs
• 저장 온도: 2-8°C
• SMILES string: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
• InChI key: WIHMBLDNRMIGDW-UHFFFAOYSA-N
• 유전자 정보: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

설명

일반 설명

Citalopram is a bicyclic phthalene derivative. It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment. It is used to treat obsessive compulsive disorder, panic disorder, sociophobia and premenstrual dysphoric disorder.

애플리케이션

Citalopram hydrobromide has been used:

• to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice
• to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats
• for 5-hydroxytryptamine (5-HT) competition uptake assays

생화학적/생리학적 작용

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

특징 및 장점

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H336,H361d,H412
• 예방조치 성명서: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• 표적 기관: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)