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Merck
모든 사진(1)

문서

M0443

Sigma-Aldrich

Mirtazapine

≥98% (HPLC)

동의어(들):

1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C17H19N3
CAS Number:
85650-52-8
Molecular Weight:
265.35
MDL number:
MFCD00865427
UNSPSC 코드:
12352200
PubChem Substance ID:
24724531
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

색상

white

solubility

DMSO: 8 mg/mL, clear

SMILES string

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

InChI key

RONZAEMNMFQXRA-UHFFFAOYSA-N

유전자 정보

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , DRD2(1813) , DRD3(1814) , DRD4(1815) , HRH1(3269) , HTR1A(3350) , HTR2A(3356) , HTR2C(3358) , HTR7(3363)
mouse ... Slc6a2(20538)
rat ... Adra1a(29412) , Drd1a(24316) , Drd2(24318) , Htr1a(24473) , Htr2a(29595) , Htr2c(25187) , Slc6a3(24898) , Slc6a4(25553)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT1A mediated serotonergic signaling are increased.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

표적 기관

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

M A Raji et al.
The Annals of pharmacotherapy, 35(9), 1024-1027 (2001-09-28)
Depression in patients with Alzheimer disease is a treatable cause of functional decline, caregiver burden, and mortality. It is often associated with severe weight loss, insomnia, and anxiety. These symptoms independently and collaboratively further worsen the prognosis of these vulnerable
B Milne et al.
British journal of pharmacology, 155(8), 1264-1278 (2008-09-23)
Ultra-low doses of opioid receptor antagonists augment spinal morphine antinociception and block the induction of tolerance. Considering the evidence demonstrating functional and physical interactions between the opioid and alpha(2)-adrenoceptors, this study investigated whether ultra-low doses of alpha(2)-adrenoceptor antagonists also influence
S A Anttila et al.
CNS drug reviews, 7(3), 249-264 (2001-10-19)
The novel antidepressant mirtazapine has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors. It enhances, therefore
Michael Paulzen et al.
Psychopharmacology, 232(4), 807-813 (2014-08-26)
The aim of this study was to investigate the distribution pattern of mirtazapine and its metabolite normirtazapine (N-desmethylmirtazapine) in blood and cerebrospinal fluid (CSF). Concentrations of mirtazapine were measured in blood serum and CSF of 16 patients treated with daily
Hun Soo Chang et al.
Journal of clinical psychopharmacology, 34(4), 446-454 (2014-06-10)
We tested for the association of HTR1A and 5-HTT genetic polymorphisms with treatment response to mirtazapine and evaluated the interactive effect between the polymorphisms in 283 patients with major depressive disorder. Korean subjects with diagnosis of major depressive disorder using
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