C8124

CH-223191

≥98% (HPLC), powder, AhR antagonist

• 동의어(들): 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phen yl-1H-pyrazole-5-carboxamide, 2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide
• 실험식(Hill 표기법): C₁₉H₁₉N₅O
• CAS Number: 301326-22-7
• Molecular Weight: 333.39
• MDL number: MFCD00377884
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329775161
• NACRES: NA.77

속성

• 제품명: CH-223191,
• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: powder
• 색상: orange-brown
• solubility: DMSO: ≥20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cc1cc(ccc1NC(=O)c2ccnn2C)\N=N\c3ccccc3C
• InChI: 1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+
• InChI key: LKTNEXPODAWWFM-GHVJWSGMSA-N

설명

애플리케이션

CH-223191 has been used as aryl hydrocarbon receptor (AHR) antagonist in HepaRG cells, TH17-IL-10+ cells and organoids.

생화학적/생리학적 작용

CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It inhibited TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibited TCDD-induced luciferase activity with an IC50 of 30nM. Unlike some other AhR antagonists which display agonist activity at high concentrations, CH-223191 did not stimulate AhR-dependent transcription even at 100 micromolar. It is also specific for AhR, displaying no affinity for the estrogen receptor, as some other antagonists do.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable