D3179

2-Deoxy-D-glucose

≥98% (GC), BioXtra

• 동의어(들): 2-Deoxy-D-arabinohexose
• 실험식(Hill 표기법): C₆H₁₂O₅
• CAS Number: 154-17-6
• Molecular Weight: 164.16
• Beilstein: 1723331
• EC Number: 205-823-0
• MDL number: MFCD00151328
• UNSPSC 코드: 12352201
• PubChem Substance ID: 24893732
• NACRES: NA.25

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 제품 라인: BioXtra
• 분석: ≥98% (GC)
• 양식: powder
• 기술: gas chromatography (GC): suitable
• 불순물: ≤0.001% Phosphorus (P); <0.1% Insoluble matter
• 무기 잔류물: <0.1%
• 색상: white
• mp: 146-147 °C (lit.)
• solubility: H₂O: 1 M at 20 °C, clear, colorless
• 음이온 미량물: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• 양이온 미량물: Al: ≤0.0005%; Ca: ≤0.003%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.001%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• 저장 온도: 2-8°C
• SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
• InChI: 1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
• InChI key: VRYALKFFQXWPIH-PBXRRBTRSA-N

설명

애플리케이션

2-Deoxy-D-glucose was used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress. It was used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR).

생화학적/생리학적 작용

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its action on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increases ROS production, and activate AMPK.

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

기타 정보

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)