추천 제품
제품명
Desipramine hydrochloride, ≥98% (TLC), powder
Quality Level
분석
≥98% (TLC)
양식
powder
색상
white to off-white
solubility
H2O: 50 mg/mL
주관자
Sanofi Aventis
저장 온도
2-8°C
SMILES string
Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
InChI
1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChI key
XAEWZDYWZHIUCT-UHFFFAOYSA-N
유전자 정보
human ... SLC6A2(6530)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.
애플리케이션
Desipramine hydrochloride has been used:
- to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
- to protect unselective damage to the noradrenergic system
- as a norepinephrine re-uptake inhibitor to treat rats for lesioning
생화학적/생리학적 작용
Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.
Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 4 nM) than the serotonin transporter (Ki = 61 nM).
특징 및 장점
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
주의사항
Hygroscopic
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
이미 열람한 고객
Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation
Li S, et al.
Journal of Neurophysiology (2007)
Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease
Tillerson J L, et al.
Neuroscience, 119(3), 899-911 (2003)
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy
Max M B, et al.
The New England Journal of Medicine, 326(19), 1250-1256 (1992)
Desipramine
reference module in biomedical sciences (2018)
Ernest Dallé et al.
Oxidative medicine and cellular longevity, 2020, 1941480-1941480 (2020-04-11)
Nonmotor symptoms (NMS) such as anxiety, depression, and cognitive deficits are frequently observed in Parkinson's disease (PD) and precede the onset of motor symptoms by years. We have recently explored the short-term effects of Fluvoxamine, a selective serotonin reuptake inhibitor
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.