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주요 문서

COO/COA

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D4268

N^G,N^G-Dimethylarginine dihydrochloride

Name: NG,NG-Dimethylarginine dihydrochloride
Brand: SIGMA

≥98% (TLC), powder, NOS inhibitor

동의어(들):

asym-Dimethylarginine, ADMA

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모든 사진(1)

About This Item

실험식(Hill 표기법):

C₈H₁₈N₄O₂ · 2HCl

CAS Number:

220805-22-1

Molecular Weight:

275.18

MDL number:

MFCD00270857

UNSPSC 코드:

12352209

PubChem Substance ID:

24278027

NACRES:

NA.77

추천 제품

Slide 1 of 10

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Sigma-Aldrich

D0627

N⁶,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

Sigma-Aldrich

M7033

N^G-Methyl-L-arginine acetate salt

Sigma-Aldrich

D0260

N⁶,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

Sigma-Aldrich

D0390

N^G,N^G′-Dimethyl-L-arginine di(p-hydroxyazobenzene-p′-sulfonate) salt

Sigma-Aldrich

311204

N^G,N^G′-Dimethyl-L-arginine, Dihydrochloride

Sigma-Aldrich

SMB00938

Dimethyl-L-arginine

Sigma-Aldrich

311203

N^G,N^G-Dimethyl-L-arginine, Dihydrochloride

Sigma-Aldrich

H3149

Heparin sodium salt from porcine intestinal mucosa

Sigma-Aldrich

R2625

Retinoic acid

Sigma-Aldrich

H3393

Heparin sodium salt from porcine intestinal mucosa

제품명

N^G,N^G-Dimethylarginine dihydrochloride,

분석

≥98% (TLC)

Quality Level

200

양식

powder

solubility

water: 50 mg/mL, clear, colorless

저장 온도

room temp

SMILES string

Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI key

SYLNVYJOPZWPJI-ILKKLZGPSA-N

유전자 정보

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

일반 설명

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

애플리케이션

N^G,N^G- Dimethylarginine dihydrochloride has been used:

to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
as a standard for measuring L-arginine and dimethylarginines
to study its effects on hepatic deterioration

생화학적/생리학적 작용

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 6

1 of 6

Sigma-Aldrich

C7629

L-Citrulline

Supelco

90538

L-Arginine monohydrochloride

Sigma-Aldrich

T1660

Nε,Nε,Nε-Trimethyllysine hydrochloride

Sigma-Aldrich

11009

L-Arginine

Sigma-Aldrich

8.52310

Fmoc-SDMA(Boc)2-ONa

Sigma-Aldrich

O5250

D-Ornithine monohydrochloride

Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta: The LOVE - COARCT Study.

José D Martins et al.

Journal of the American Heart Association, 8(7), e011536-e011536 (2019-04-02)

Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment)

Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation.

Aleksandar Radujkovic et al.

Haematologica, 104(4), 827-834 (2018-12-06)

Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft-versus-host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant

Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients-A Pilot Study

Nemeth B, et al.

In Vivo, 30(5), 663-669 (2016)

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure.

P Vallance et al.

Lancet (London, England), 339(8793), 572-575 (1992-03-07)

Nitric oxide (NO), synthesised from L-arginine, contributes to the regulation of blood pressure and to host defence. We describe in-vitro and in-vivo evidence that NO synthesis can be inhibited by an endogenous compound, NG,NG-dimethylarginine (asymmetrical dimethylarginine, ADMA). In man, this

Asymmetric dimethylarginine predicts the risk of contrast-induced acute kidney injury in patients undergoing cardiac catheterization.

Tse-Min Lu et al.

Atherosclerosis, 254, 161-166 (2016-10-17)

Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. We measured plasma ADMA

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문서

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

주요 문서

N^G,N^G-Dimethylarginine dihydrochloride

≥98% (TLC), powder, NOS inhibitor

About This Item

추천 제품

속성

제품명

분석

Quality Level

양식

solubility

저장 온도

SMILES string

InChI

InChI key

유전자 정보

설명

일반 설명

애플리케이션

생화학적/생리학적 작용

안전성 정보

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

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