D6899

Diclofenac sodium salt

• 동의어(들): 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
• 실험식(Hill 표기법): C₁₄H₁₀Cl₂NNaO₂
• CAS Number: 15307-79-6
• Molecular Weight: 318.13
• EC Number: 239-346-4
• MDL number: MFCD00082251
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277712
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: powder
• mp: 283-285 °C
• solubility: methanol: 50 mg/mL, clear, colorless to faint yellow or tan
• 주관자: Novartis
• 저장 온도: room temp
• SMILES string: [Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• InChI key: KPHWPUGNDIVLNH-UHFFFAOYSA-M
• 유전자 정보: human ... PTGS1(5742) , PTGS2(5743)

설명

애플리케이션

Diclofenac sodium has been used:

• to investigate its radioprotective potential in a study
• to determine the basic viscosity and hydrodynamic values of the solubilizers and their micellar adducts in a study
• as a standard for potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system
• to inhibit phase II drug metabolizing enzyme (DME) in a study to investigate the inhibitory effects of an ethanol extract of Descurainia sophia seeds on Phase I and II DMEs

생화학적/생리학적 작용

Diclofenac sodium salt is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a competitive and irreversible inhibitor of prostaglandin synthetase. Its analgesic and anti-inflammatory activities are based on the prevention of the synthesis of arachinodate metabolites via cyclooxygenase inhibition. It is found to hinder the conversion of arachidonic acid to prostaglandins, which mediate inflammatory process. The NSAIDs are found to inhibit both cyclooxygenase enzymes, COX-1 and COX-2, causing undesirable gastrointestinal effect. Diclofenac sodium also functions as a scavenger of free radicals and serves a radioprotective role in restoring supercoiled form of plasmid DNA damaged by radiation back to normal. Diclofenac sodium is oxidized by the donation of electron and transfer of hydrogen atom. It can be a potential radioprotective agent.

Standard NSAID and cyclooxygenase (COX) inhibitor. Major metabolites are 4´-hydroxydiclofenac and 5´-hydroxydiclofenac. Has been used as substrate selective for CYP2C9.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06,GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H361d,H372,H411
• 예방조치 성명서: P202 - P260 - P264 - P273 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges