K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

• 동의어(들): 2-(3-Benzoylphenyl)propionic acid
• 실험식(Hill 표기법): C₁₆H₁₄O₃
• CAS Number: 22071-15-4
• Molecular Weight: 254.28
• EC Number: 244-759-8
• MDL number: MFCD00055790
• UNSPSC 코드: 12352200
• PubChem Substance ID: 57654315
• NACRES: NA.77

속성

• product name: Ketoprofen, ≥98% (TLC)
• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥98% (TLC)
• 형태: powder
• solubility: ethanol: 50 mg/mL, clear, colorless to yellow
• 주관자: Bayer
• SMILES string: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
• InChI key: DKYWVDODHFEZIM-UHFFFAOYSA-N
• 유전자 정보: human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

설명

일반 설명

Ketoprofen belongs to the class of 2-arylpropionic acid.

애플리케이션

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

생화학적/생리학적 작용

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.

Non-steroidal anti-inflammatory compound that is selective for COX-1.

특징 및 장점

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H400
• 예방조치 성명서: P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges