E2011

cis-5,8,11,14,17-Eicosapentaenoic acid

from fish oil, ≥99% (GC), liquid, 5-Lipoxygenase inhibitor

• 동의어(들): EPA, Timnodonic acid
• Linear Formula: CH₃(CH₂CH=CH)₅(CH₂)₃CO₂H
• CAS Number: 10417-94-4
• Molecular Weight: 302.45
• Beilstein: 1714433
• MDL number: MFCD00065716
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24894450
• NACRES: NA.77

속성

• product name: cis-5,8,11,14,17-Eicosapentaenoic acid, ≥99%
• 생물학적 소스: fish oil
• Quality Level: 200
• 분석: ≥99%
• 형태: liquid
• refractive index: n20/D 1.4977 (lit.)
• mp: −54-−53 °C (lit.)
• solubility: methanol: 50 mg/mL, clear, colorless
• density: 0.943 g/mL at 25 °C (lit.)
• 저장 온도: −20°C
• SMILES string: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
• InChI: 1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
• InChI key: JAZBEHYOTPTENJ-JLNKQSITSA-N
• 유전자 정보: human ... ALOX5(240) ; mouse ... ALOX5(11689) , Pparg(19016) ; rat ... ALOX5(25290)

설명

일반 설명

Eicosapentaenoic acid is a polyunsaturated fatty acid (PUFAs) and is synthesized from linolenic acid. It is distributed in phospholipid bilayers of the cell membrane, synaptic membranes of the brain and retina. It is obtained majorly from fish oil, seaweed, phytoplankton, and camelina. Being an Omega-3 fatty acid, it shows cis-trans conformations.

애플리케이션

cis-5,8,11,14,17-Eicosapentaenoic acid has been used:

• to test pharmacologic effect on steatosis in hepatocytes
• as an analytical standard in Raman spectra measurements to characterize human breast cancer samples
• in lipid peroxidation assay in mouse embryonic fibroblasts and in pre-treatment of cells for cell viability studies

생화학적/생리학적 작용

Eicosapentaenoic acid (EPA) is essential for healthy living and alleviates obesity. It decreases the triglyceride levels by modulating very-low-density lipoprotein(VLDL) levels.

5-Lipoxygenase inhibitor; reduces thromboxane A₂ production.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): 200.1 °F - closed cup
• Flash Point (°C): 93.4 °C - closed cup
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter