E3763

Resorufin ethyl ether

≥98% (TLC), powder

• 동의어(들): 7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O⁷-Ethylresorufin
• 실험식(Hill 표기법): C₁₄H₁₁NO₃
• CAS Number: 5725-91-7
• Molecular Weight: 241.24
• Beilstein: 225973
• MDL number: MFCD00037661
• UNSPSC 코드: 12161501
• PubChem Substance ID: 24894527
• NACRES: NA.47

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 형태: powder
• 저장 조건: (Tightly closed. Dry)
• 기술: activity assay: suitable
• 색상: orange to red
• mp: 223-225 °C (lit.)
• solubility: chloroform: 9.80-10.20 mg/mL, clear, orange
• 적합성: suitable for fluorescence
• 저장 온도: −20°C
• SMILES string: CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F
• InChI: 1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3
• InChI key: ZOSYTBPPLWBBKM-UHFFFAOYSA-N

설명

일반 설명

Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.

Resorufin is the reduced product of resazurin, also termed as Alamar Blu. It exhibits fluorescence at longer wavelengths and is flexible for modification in its hydroxyl group.

Research area: Cell Signaling

애플리케이션

Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).

기질

Fluorimetric substrate for cytochrome P450 linked enzyme, CXPIA1/2

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)