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Merck
모든 사진(2)

문서

F5012

Sigma-Aldrich

Anti-Ferritin, Human antibody produced in rabbit

whole antiserum, liquid

동의어(들):

Anti-FHC, Anti-FTH, Anti-FTHL6, Anti-HFE5, Anti-PIG15, Anti-PLIF

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.46

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

whole antiserum

항체 생산 유형

primary antibodies

클론

polyclonal

형태

liquid

포함

15 mM sodium azide

종 반응성

human

기술

Ouchterlony double diffusion: 1:16

UniProt 수납 번호

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... FTH1(2495)

일반 설명

Ferritin, an iron-storage protein is usually present in the liver and spleen in mammals. Iron and ferritin are distributed relatively same in the eye. Ferritin is made up of heavy and light chains.

면역원

Ferritin isolated from normal human spleen

애플리케이션

  • Anti-Ferritin, Human antibody produced in rabbit has been used in:
  • immunohistochemistry
  • western blotting
  • immunocytochemical techniques

Anti-Ferritin, Human antibody is suitable for use in Ouchterlony double diffusion (1:16 using human spleen ferritin), and immunoelectrophoresis. The antibody may also be used in western blot (1:1000 using frozen liver homogenates) and immunoprecipitation (using 300 μg of cell lysate incubated with 6 mul of anti-ferritin for 1h at 4 ° C).
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

생화학적/생리학적 작용

Ferritin is an iron-storage protein that regulates iron-homeostasis in cells. While mitochondrial ferritin is a homopolymer, the cytosolic form consists of heteropolymeric L- and H-chains. Genetic mutations in ferritin L-chains have been associated with neurodegenerative disorders, whereas altered levels of ferritin have been linked to hemophagocytic lymphohistiocytosis and adult-onset Still′s disease . In immunoelectrophoresis, anti-ferritin, human antibody is specific for ferritin when used against human spleen extract and purified ferritin. No reactivity is observed against normal human serum.

제조 메모

The antiserum has been treated to remove lipoproteins.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Scientific tests
Aldred EM, et al.
Pharmacology, 331-341 (2009)
Increased Iron Sequestration in Alveolar Macrophages in Chronic Obtructive Pulmonary Disease
Philippot Q, et al.
Testing, 9(5), e96285-e96285 (2014)
Moon-Suhn Ryu et al.
The Journal of clinical investigation, 127(5), 1786-1797 (2017-04-05)
Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic
Zhao Wang et al.
International journal of hematology, 90(4), 501-505 (2009-08-06)
Elevated levels of serum ferritin and a low percentage of glycosylated ferritin have been reported in adult-onset Still's disease (AOSD) as well as in hemophagocytic lymphohistiocytosis (HLH). The objective of the current study was to investigate total ferritin levels and
Pro-inflammatory activation of microglia in the brain of patients with sepsis
Zrzavy T, et al.
Neuropathology and Applied Neurobiology, 45(3), 278-290 (2019)

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