H2500

Hemoglobin from bovine blood

lyophilized powder

• 동의어(들): Bovine hemoglobin, Hb, Methemoglobin
• CAS Number: 9008-02-0
• MDL number: MFCD00131282
• UNSPSC 코드: 12352202
• eCl@ss: 42030116
• NACRES: NA.61

속성

• 생물학적 소스: bovine blood
• 형태: lyophilized powder
• 분자량: M_r ~64500
• 기술: MALDI-TOF: suitable
• UniProt 수납 번호: P01966; P02070; P02081; P06642; P06643
• 저장 온도: 2-8°C
• 유전자 정보: cow ... HBA1(281221) , HBB(280813) , HBE2(513240) , HBE4(513108) , HBG(511735) , alpha globin(512439)

설명

일반 설명

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is a globular protein with α and β chains with each 141 and 146 amino acids, respectively. It exists as a tetramer with each monomer having heterocyclic porphyrin ring with iron constituting the heme.

애플리케이션

Hemoglobin from bovine blood has been used in:

• standard curve generation for the quantification intraparenchymal hemorrhage and parenchymal hemorrhage in spinal cord homogenate using Drabkin′s assay, Quadrupole-Ion Mobility-Time-of-Flight mass spectrometery
• the generation of molecularly imprinted polymers (MIPs) to mimic high molecular-weight polyethylene glycol (PEG) in crystallization studies

The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials.

생화학적/생리학적 작용

Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide. Bovine hemoglobin is used in the generation of hemoglobin-vesicles (HbV) for oxygen transport. It is thermally stable and displays high affinity to oxygen when compared to human hemoglobin. Bovine hemoglobin interacts with synthetic and azo dyes. Polymerized forms of bovine haemoglobin is recommended for treating autoimmune hemolytic anemia.

Oxygen transporter. The Fe²⁺/Fe³⁺ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.

주의사항

Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)