추천 제품
제품명
Interleukin-17A human, IL-17A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
생물학적 소스
human
Quality Level
재조합
expressed in HEK 293 cells
분석
≥95% (SDS-PAGE)
양식
lyophilized powder
효능
≤2 ng/mL EC50
품질
endotoxin tested
분자량
dimer 30-35 kDa (glycosylated)
포장
pkg of 10 μg
기술
cell culture | mammalian: suitable
불순물
≤1 EU/μg
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... IL17A(3605)
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생화학적/생리학적 작용
IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
IL-17A belongs to the IL-17 family and is produced by Th17 cells, a subset of T helper cells. Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis. IL-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines, upregulates production of growth factors that promote angiogenesis, and enhances expression of adhesion molecules in fibroblasts.
물리적 형태
Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl pH 7.4+ 250 mM NaCl
제조 메모
HumanKine Interleukin-17A (IL-17A), expressed in human HEK 293 cells, is a glycosylated homodimer with an apparent molecular mass of 30-35 kDa due to glycosylation. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
분석 메모
The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF adult fibroblasts.
법적 정보
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Shu Zhu et al.
The Journal of experimental medicine, 207(12), 2647-2662 (2010-11-17)
Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals triggered by this powerful inflammatory cytokine are controlled to avoid abnormal inflammatory responses is not well understood. In this
Michael Notaras et al.
Molecular psychiatry (2021-06-24)
It is widely accepted that narcotic use during pregnancy and specific environmental factors (e.g., maternal immune activation and chronic stress) may increase risk of neuropsychiatric illness in offspring. However, little progress has been made in defining human-specific in utero neurodevelopmental
Junhua Wang et al.
PLoS neglected tropical diseases, 9(5), e0003755-e0003755 (2015-05-09)
The growth potential of the tumor-like Echinococcus multilocularis metacestode (causing alveolar echinococcosis, AE) is directly linked to the nature/function of the periparasitic host immune-mediated processes. We previously showed that Fibrinogen-like-protein 2 (FGL2), a novel CD4+CD25+ Treg effector molecule, was over-expressed
H Xiong et al.
International endodontic journal, 48(6), 505-511 (2014-07-22)
To investigate IL-17 expression in human pulpitis and to study the effects of IL-17 on the secretion of the chemokines IL-6 and IL-8 and the related signalling pathways. Samples of human dental pulp tissue were obtained from healthy controls and
Thomas Fabre et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3925-3933 (2014-09-12)
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have
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