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Merck
모든 사진(4)

문서

I3636

Sigma-Aldrich

Acridine Mutagen ICR 191

동의어(들):

6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride

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모든 사진(4)

About This Item

실험식(Hill 표기법):
C19H21Cl2N3O · 2HCl
CAS Number:
17070-45-0
Molecular Weight:
451.22
Beilstein:
8176205
EC Number:
241-129-4
MDL number:
MFCD00013320
UNSPSC 코드:
12171500
PubChem Substance ID:
24896042
NACRES:
NA.32

solubility

DMSO: soluble

Quality Level

200

적합성

suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard)

저장 온도

2-8°C

SMILES string

Cl[H].Cl[H].COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1

InChI

1S/C19H21Cl2N3O.2ClH/c1-25-14-4-6-17-16(12-14)19(23-9-2-8-22-10-7-20)15-5-3-13(21)11-18(15)24-17;;/h3-6,11-12,22H,2,7-10H2,1H3,(H,23,24);2*1H

InChI key

LMEMIKWTNPWYMI-UHFFFAOYSA-N

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관련 카테고리

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H300 + H310 + H330,H350

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

시험 성적서(COA)

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문서 라이브러리 방문

M Watanabe et al.
Mutation research, 314(1), 27-37 (1994-01-01)
The specificity of frameshift mutations induced by several classes of chemical mutagens was determined using a collection of mutant E. coli lacZ genes. This collection can detect each of five kinds of specific frameshift events by scoring Lac+ revertant colonies.
K L Dobo et al.
Mutagenesis, 10(1), 53-58 (1995-01-01)
In order to investigate the influence of loss of heterozygosity (LOH) events on mutation rate, we studied two closely related human lymphoblastoid cell lines, AHH-1 (h2E1.v2) and MCL-5, which are heterozygous at the tk locus (chromosome 17q23-25). Although they have
N F Cariello et al.
Mutation research, 414(1-3), 95-105 (1998-06-19)
We report the first use of green fluorescent protein (GFP) for mutation detection. We have constructed a plasmid-based bacterial system whereby mutated cells fluoresce and non-mutated cells do not fluoresce. Fluorescence is monitored using a simple hand-help UV lamp; no
S A Taft et al.
Environmental and molecular mutagenesis, 23(2), 96-100 (1994-01-01)
Human TK6 lymphoblasts were treated with the acridine derivative ICR-191, and mutants at the hprt locus were isolated. Mutant hprt cDNA was reverse-transcribed from mRNA, amplified by polymerase chain reaction (PCR), and sequenced. Additions of single G:C base pairs (+1
W D Chen et al.
Journal of the National Cancer Institute, 92(6), 480-485 (2000-03-16)
Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite instability are recognizable by their high rate of spontaneous frameshift mutations within microsatellite sequences, their resistance to killing by cytotoxic
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